2. Natural Products
  3. Alkaloids
  4. Acridone Alkaloids

Acridone Alkaloids

Acridone Alkaloids (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W748415
    Acronycine 7008-42-6
    Acronycine (Acronine) is an acridone alkaloid.
    Acronycine
  • HY-N16745
    5-Hydroxynoracronycine 27067-70-5
    5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC50 of 93.1 μmol/L against HIV-1 protease and an IC50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases.
    5-Hydroxynoracronycine
  • HY-N17251
    Cusculine 143438-95-3
    Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC50 of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever.
    Cusculine
  • HY-W437569
    Melicopine 568-01-4
    Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields.
    Melicopine
  • HY-N8364
    Evoxanthine 477-82-7
    Evoxanthine is a compound that can be isolated from the stem bark of Pleiocarpa pycnantha.
    Evoxanthine